This tier includes multi-drug resistant bacteria that are particularly dangerous in hospitals and nursing homes. They can cause life-threatening infections such as sepsis and pneumonia.

| Pathogen | Key Resistance | |----------|----------------| | Acinetobacter baumannii | Carbapenem-resistant | | Pseudomonas aeruginosa | Carbapenem-resistant | | Enterobacteriaceae (e.g., E. coli , Klebsiella pneumoniae ) | Carbapenem-resistant, 3rd-gen cephalosporin-resistant |

The list serves as a roadmap for scientists, investors, and policymakers to focus on bacteria for which new treatments are most desperately needed. 1. Critical Priority

(Significant but lower urgency)

(e.g., Klebsiella pneumoniae , E. coli ) 3rd generation cephalosporin-resistant Enterobacterales Rifampicin-resistant Mycobacterium tuberculosis (RR-TB) 2. High Priority: High-Burden and Community Threats