The season begins with "Riot" (Episode 1), where we see Michael Scofield alive and in a wheelchair, living a quiet life in Afghanistan with his wife, Sara Tancredi (Sarah Wayne Callies), and their son. However, his peaceful life is short-lived, as he receives a package that sets him on a mission to rescue his brother, Lincoln Burrows (Dominic Purcell), who is on death row in Yemen. This sets the stage for a thrilling adventure that takes Michael to various countries, including Yemen, Morocco, and Cambodia.