MOGI-131 is a potent, selective, and brain-penetrant GPR139 agonist with robust preclinical efficacy in depression, nicotine withdrawal, and motivational deficits. Its favorable pharmacokinetics and safety profile support progression toward first-in-human studies. As a tool compound, it will enable critical mechanistic dissection of GPR139’s role in reward, aversion, and mood regulation.
In the chronic unpredictable mild stress (CUMS) mouse model, MOGI-131 (3–10 mg/kg, oral) reversed sucrose preference deficits and reduced immobility time in the forced swim test (FST) without affecting locomotor activity. Effects were absent in GPR139 knockout mice, confirming on-target activity. mogi-131
While the term "mogi-131" might not be widely recognized, it appears to be linked to a specific aspect of seismology. Further research and context are needed to fully understand the significance of Mogi-131. If you're interested in learning more, please provide additional context or clarify what you would like to know about Mogi-131. MOGI-131 is a potent, selective, and brain-penetrant GPR139
If you provide more context, I'll do my best to create a well-researched and informative write-up for you. In the chronic unpredictable mild stress (CUMS) mouse
is a specific production code within the Japanese adult video (JAV) industry, representing a debut release featuring the actress Moka Ayase . Released in early 2024, the title is part of the "Mogitate Amateur" (Freshly Picked Amateur) series produced by SOD Create . Production Background
The release is approximately long and falls under various industry categories: