For the first two seasons, Sara Tancredi (played by Sarah Wayne Callies) is the moral compass of the show. As the prison doctor at Fox River, she falls in love with Michael Scofield. By the end of Season 2, their romance is in full bloom, but the law is catching up to her. She is arrested for aiding Michael’s escape and faces a lengthy prison sentence.
It was revealed that the head in the box was a prop used by Gretchen Morgan to traumatize Lincoln.
: Sara is arrested for the murder of Christina Scofield and sent to a women's prison. Michael eventually sacrifices himself (or so it seems at the time) to help her escape.