Sone-214

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Sone-214 is a highly selective and potent inhibitor of the c-MET signaling pathway. By binding to the ATP-binding site of the c-MET receptor, Sone-214 effectively blocks the activation of downstream signaling pathways, thereby inhibiting the downstream effects of c-MET signaling. Specifically, Sone-214 has been shown to prevent the recruitment of p85 subunit of PI3K to c-MET, leading to a reduction in the activation of the PI3K/AKT signaling cascade and the subsequent suppression of cell growth and survival pathways. sone-214

| Model | Read‑out | Result | |-------|----------|--------| | Human THP‑1 monocytes (luciferase reporters) | IFN‑β induction | EC₅₀ ≈ 45 nM | | Human peripheral blood mononuclear cells (PBMCs) | IFN‑α/β, CXCL10, IL‑6 | IFN‑α/β ↑ 12‑fold, IL‑6 ↑ 1.3‑fold (vs. cGAMP: 8‑fold IFN, 5‑fold IL‑6) | | Mouse RAW264.7 macrophages | Phospho‑IRF3, phospho‑p65 (Western blot) | Strong IRF3, weak p65 phosphorylation | If you could provide more details about "sone-214",

Here are the detailed features of this specific title: Specifically, Sone-214 has been shown to prevent the